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Examples of brand names include: Abbott Optium Plus; Abbott Freestyle; Accu‐Chek Aviva; Accu‐Chek Active; Accu‐Chek Advantage; Accu Chek Compact; Bayer Contour; Bayer Contour NEXT; One Touch Ultra; One Touch Verio Flex; and One Touch Verio.Aetna considers devices to measure glycated serum proteins (fructosamine) (e.g., Duet™ Glucose Control System by LXN Corporation) experimental and investigational.

The authors reported that 69.4 % of the patients found the I-Port useful and helpful in the management of their diabetes and there was no significant difference in patient's glycosylated albumin between SI, single I-Port, and Dual I-Port treatment regimens.The presence of GAD autoantibodies has been shown to be a strong predictive marker for the eventual onset of type 1 diabetes.Measurement of anti-GAD antibodies has been proposed for evaluating the risk of developing type 1 diabetes in persons at high risk.Glutamic acid decarboxylase (GAD) is an enzyme that is produced primarily by pancreatic islet cells.A number of recent studies indicate that patients with type 1 diabetes often have antibodies to GAD and several other islet cell antigens.However, the value of such testing is unproven, as there are no measures that have been demonstrated to be effective in preventing the onset of type 1 diabetes.

Guidelines from the Canadian Diabetes Association (Ur et al, 2003) explain that the loss of pancreatic beta cells in persons who subsequently develop type 1 diabetes passes through a subclinical prodrome that can be detected reliably in first- and second-degree relatives of persons with type 1 diabetes by the presence of anti-GAD antibodies and other pancreatic islet cell autoantibodies in their sera.

Guidelines from the Royal Australian College of General Practitioners (RACGP, 2007) explained that measurement of GAD can be of particular use in diagnosing Late onset Autoimmune Diabetes in Adults (LADA), a form of late onset diabetes that is autoimmune and requires treatment with insulin within a relatively short period of time after diagnosis (often within the next 2 years).

RACGP guidelines explained that persons with LADA tend to be young (30 to 40 years of age, lean, and have a personal and/or family history of other autoimmune diseases (e.g., hypo- or hyper-thyroidism).

Since the biomarkers are a combination of proteins and metabolites, they are measured using several different methods: ion-exchange high-performance liquid chromatography (Hb A1c), chemiluminescent immunoassay (ferritin and interleukin 2 receptor alpha [IL2-Rα]), enzymatic (glucose), immuno-turbidometric assay (C-reactive protein [CRP]), and an enzyme-linked immunosorbent assay (adiponectin and insulin).

The Pre Dx DRS is used for patients who do not have type 2 diabetes (T2D) but are at increased risk for developing this condition.

Patients to be considered include those with impaired fasting glucose, metabolic syndrome, or other risk factors, including family history, age In a prospective, randomized study, Blevins et al (2008) compared the I-Port to standard multiple dose insulin administration in diabetic patients receiving insulin injections (n = 74).

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